Journal of Comprehensive Pediatrics

Published by: Kowsar

Comparison of the Therapeutic Effect of Anti-D IG and IVIG in Children with Acute Immune Thrombocytopenic Purpura Attending a Children’s Medical Center: A Randomized, Double-Blind, Controlled Clinical Trial

Leili Koochakzadeh 1 , Kiavoosh Fekri 1 , Reza Pakzad 2 and Mehdi Khabazkhoob 3 , *
Authors Information
1 Department of Pediatrics, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
2 Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, IR Iran
3 Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Journal of Comprehensive Pediatrics: February 2018, 9 (1); e12334
  • Published Online: November 30, 2017
  • Article Type: Research Article
  • Received: April 30, 2017
  • Accepted: November 20, 2017
  • DOI: 10.5812/compreped.12334

To Cite: Koochakzadeh L, Fekri K, Pakzad R, Khabazkhoob M. Comparison of the Therapeutic Effect of Anti-D IG and IVIG in Children with Acute Immune Thrombocytopenic Purpura Attending a Children’s Medical Center: A Randomized, Double-Blind, Controlled Clinical Trial, J Compr Ped. 2018 ;9(1):e12334. doi: 10.5812/compreped.12334.

Abstract
Copyright © 2017, Journal of Comprehensive Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
Footnotes
References
  • 1. Segel GB, Feig SA. Chronic Complex Diseases of Childhood: A Practical Guide for Clinicians. Morimoto K. Immune Thrombocytopenic Purpura (ITP). In: Yazdani S, McGhee S, Stiehm ER, editors. Florida, Unaited States: Brown Walker Press, Boca Roton; 2011. p. 268-71.
  • 2. Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux S. Nathan and Oski's Hematology of Infancy and Childhood E-Book. Elsevier Health Sciences; 2008.
  • 3. Lusher JM, Zuelzer WW. Idiopathic thrombocytopenic purpura in childhood. J Pediatr. 1966;68(6):971-9. [PubMed: 5949017].
  • 4. Tarantino MD, Madden RM, Fennewald DL, Patel CC, Bertolone SJ. Treatment of childhood acute immune thrombocytopenic purpura with anti-D immune globulin or pooled immune globulin. J Pediatr. 1999;134(1):21-6. [PubMed: 9880444].
  • 5. Psaila B, Petrovic A, Page LK, Menell J, Schonholz M, Bussel JB. Intracranial hemorrhage (ICH) in children with immune thrombocytopenia (ITP): study of 40 cases. Blood. 2009;114(23):4777-83. doi: 10.1182/blood-2009-04-215525. [PubMed: 19767509].
  • 6. Ahn YS, Harrington WJ. Treatment of idiopathic thrombocytopenic purpura (ITP). Annu Rev Med. 1977;28:299-309ENG. doi: 10.1146/annurev.me.28.020177.001503. [PubMed: 324364].
  • 7. Cines DB, Bussel JB. How I treat idiopathic thrombocytopenic purpura (ITP). Blood. 2005;106(7):2244-51. doi: 10.1182/blood-2004-12-4598. [PubMed: 15941913].
  • 8. Bussel JB, Hilgartner MW. The use and mechanism of action of intravenous immunoglobulin in the treatment of immune haematologic disease. Br J Haematol. 1984;56(1):1-7. [PubMed: 6367804].
  • 9. Bussel JB. Fc receptor blockade and immune thrombocytopenic purpura. Semin Hematol. 2000;37(3):261-6. [PubMed: 10942220].
  • 10. Chapel HM, Spickett GP, Ericson D, Engl W, Eibl MM, Bjorkander J. The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy. J Clin Immunol. 2000;20(2):94-100. [PubMed: 10821460].
  • 11. Sekul EA, Cupler EJ, Dalakas MC. Aseptic meningitis associated with high-dose intravenous immunoglobulin therapy: frequency and risk factors. Ann Intern Med. 1994;121(4):259-62. [PubMed: 8037406].
  • 12. Tsiouris J, Tsiouris N. Hemiplegia as a complication of treatment of childhood immune thrombocytopenic purpura with intravenously administered immunoglobulin. J Pediatr. 1998;133(5):717. [PubMed: 9821443].
  • 13. Berard R, Whittemore B, Scuccimarri R. Hemolytic anemia following intravenous immunoglobulin therapy in patients treated for Kawasaki disease: a report of 4 cases. Pediatr Rheumatol Online J. 2012;10(1):10. doi: 10.1186/1546-0096-10-10. [PubMed: 22507284].
  • 14. Markvardsen LH, Christiansen I, Harbo T, Jakobsen J. Hemolytic anemia following high dose intravenous immunoglobulin in patients with chronic neurological disorders. Eur J Neurol. 2014;21(1):147-52. doi: 10.1111/ene.12287. [PubMed: 24180709].
  • 15. Lazarus AH, Crow AR. Mechanism of action of IVIG and anti-D in ITP. Transfus Apher Sci. 2003;28(3):249-55. doi: 10.1016/S1473-0502(03)00043-0. [PubMed: 12725951].
  • 16. Imbach P, Kuhne T. Sequelae of treatment of ITP with anti-D (Rho) immunoglobulin. Lancet. 2000;356(9228):447-8. [PubMed: 10981885].
  • 17. Simpson KN, Coughlin CM, Eron J, Bussel JB. Idiopathic thrombocytopenia purpura: Treatment patterns and an analysis of cost associated with intravenous immunoglobulin and anti-D therapy. Semin Hematol. 1998;35(1 Suppl 1):58-64. [PubMed: 9523750].
  • 18. Newman GC, Novoa MV, Fodero EM, Lesser ML, Woloski BM, Bussel JB. A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura. Br J Haematol. 2001;112(4):1076-8. [PubMed: 11298610].
  • 19. Scaradavou A, Woo B, Woloski BM, Cunningham-Rundles S, Ettinger LJ, Aledort LM, et al. Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients. Blood. 1997;89(8):2689-700. [PubMed: 9108386].
  • 20. Imbach P, Barandun S, d'Apuzzo V, Baumgartner C, Hirt A, Morell A, et al. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet. 1981;1(8232):1228-31. [PubMed: 6112565].
  • 21. Cooper N, Heddle NM, Haas M, Reid ME, Lesser ML, Fleit HB, et al. Intravenous (IV) anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms: modulation of cytokine and platelet responses to IV anti-D by FcgammaRIIa and FcgammaRIIIa polymorphisms. Br J Haematol. 2004;124(4):511-8. [PubMed: 14984503].
  • 22. Alioglu B, Ercan S, Tapci AE, Zengin T, Yazarli E, Dallar Y. A comparison of intravenous immunoglobulin (2 g/kg totally) and single doses of anti-D immunoglobulin at 50 mug/kg, 75 mug/kg in newly diagnosed children with idiopathic thrombocytopenic purpura: Ankara hospital experience. Blood Coagul Fibrinolysis. 2013;24(5):505-9. doi: 10.1097/MBC.0b013e32835e5337. [PubMed: 23470649].
  • 23. Celik M, Bulbul A, Aydogan G, Tugcu D, Can E, Uslu S, et al. Comparison of anti-D immunoglobulin, methylprednisolone, or intravenous immunoglobulin therapy in newly diagnosed pediatric immune thrombocytopenic purpura. J Thromb Thrombolysis. 2013;35(2):228-33. doi: 10.1007/s11239-012-0801-z. [PubMed: 22956408].
  • 24. Dolman C, Thorpe SJ, Thorpe R. Enhanced efficacy of anti-D immunoglobulin for treating ITP is not explained by higher immunoglobulin polymer content. Biologicals. 2001;29(2):75-9. doi: 10.1006/biol.2001.0279. [PubMed: 11580212].
  • 25. El Alfy MS, Mokhtar GM, El-Laboudy MA, Khalifa AS. Randomized trial of anti-D immunoglobulin versus low-dose intravenous immunoglobulin in the treatment of childhood chronic idiopathic thrombocytopenic purpura. Acta Haematol. 2006;115(1-2):46-52. doi: 10.1159/000089465. [PubMed: 16424649].
  • 26. Kane I, Ragucci D, Shatat IF, Bussel J, Kalpatthi R. Comparison of intravenous immune globulin and high dose anti-D immune globulin as initial therapy for childhood immune thrombocytopenic purpura. Br J Haematol. 2010;149(1):79-83. doi: 10.1111/j.1365-2141.2009.08057.x. [PubMed: 20096011].
  • 27. Shahgholi E, Vosough P, Sotoudeh K, Arjomandi K, Ansari S, Salehi S, et al. Intravenous immune globulin versus intravenous anti-D immune globulin for the treatment of acute immune thrombocytopenic purpura. Indian J Pediatr. 2008;75(12):1231-5. doi: 10.1007/s12098-008-0243-y. [PubMed: 19190878].
  • 28. Son DW, Jeon IS, Yang SW, Cho SH. A single dose of anti-D immunoglobulin raises platelet count as efficiently as intravenous immunoglobulin in newly diagnosed immune thrombocytopenic purpura in Korean children. J Pediatr Hematol Oncol. 2008;30(8):598-601. doi: 10.1097/MPH.0b013e31817541ba. [PubMed: 18799936].
  • 29. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-60. doi: 10.3758/BRM.41.4.1149. [PubMed: 19897823].
  • 30. Tarantino MD, Young G, Bertolone SJ, Kalinyak KA, Shafer FE, Kulkarni R, et al. Single dose of anti-D immune globulin at 75 microg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children. J Pediatr. 2006;148(4):489-94. doi: 10.1016/j.jpeds.2005.11.019. [PubMed: 16647411].
  • 31. Yacobovich J, Abu-Ahmed S, Steinberg-Shemer O, Goldberg T, Cohen M, Tamary H. Anti-D treatment for pediatric immune thrombocytopenia: Is the bad reputation justified? Semin Hematol. 2016;53 Suppl 1:S64-6. doi: 10.1053/j.seminhematol.2016.04.019. [PubMed: 27312170].
  • 32. Blanchette V, Adams M, Wang E, McMillan J, Imbach P, Andrew M, et al. Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura. Lancet. 1994;344(8924):703-7. doi: 10.1016/s0140-6736(94)92205-5.
  • 33. Duhem C, Dicato MA, Ries F. Side-effects of intravenous immune globulins. Clin Exp Immunol. 1994;97 Suppl 1:79-83. [PubMed: 8033440].
  • 34. Katz U, Shoenfeld Y. Review: intravenous immunoglobulin therapy and thromboembolic complications. Lupus. 2005;14(10):802-8. doi: 10.1191/0961203303lu2168rr. [PubMed: 16302674].
  • 35. Eghbali A, Azadmanesh P, Bagheri B, Taherahmadi H, Sadeghi Sedeh B. Comparison between IV immune globulin (IVIG) and anti-D globulin for treatment of immune thrombocytopenia: a randomized open-label study. Fundam Clin Pharmacol. 2016;30(4):385-9. doi: 10.1111/fcp.12198. [PubMed: 26991138].
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