Journal of Comprehensive Pediatrics

Published by: Kowsar

Comparing Neonatal Outcome Following the Use of Ondansetron versus Vitamin B6 in Pregnant Females with Morning Sickness: A Randomized Clinical Trial

Zahra Shahraki 1 , Zohre Sadat Hashemi Bonjar 1 , Forough Forghani 1 , * and Rezvane Nakhai 1
Authors Information
1 Obstetrics and Gynecology Department, Zabol University of Medical Sciences, Zabol, IR Iran
Article information
  • Journal of Comprehensive Pediatrics: November 2016, 7 (4); e37081
  • Published Online: September 14, 2016
  • Article Type: Research Article
  • Received: March 28, 2016
  • Revised: July 6, 2016
  • Accepted: August 28, 2016
  • DOI: 10.17795/compreped-37081

To Cite: Shahraki Z, Hashemi Bonjar Z S, Forghani F, Nakhai R. Comparing Neonatal Outcome Following the Use of Ondansetron versus Vitamin B6 in Pregnant Females with Morning Sickness: A Randomized Clinical Trial, J Compr Ped. 2016 ; 7(4):e37081. doi: 10.17795/compreped-37081.

Copyright © 2016, Iranian Society of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Ferreira E, Gillet M, Lelievre J, Bussieres JF. Ondansetron use during pregnancy: a case series. J Popul Ther Clin Pharmacol. 2012; 19(1): 1-10[PubMed]
  • 2. Davis M. Nausea and vomiting of pregnancy: an evidence-based review. J Perinat Neonatal Nurs. 2004; 18(4): 312-28[PubMed]
  • 3. Alexander R, Lovell AT, Seingry D, Jones RM. Comparison of ondansetron and droperidol in reducing postoperative nausea and vomiting associated with patient-controlled analgesia. Anaesthesia. 1995; 50(12): 1086-8[PubMed]
  • 4. Cunningham FG, Leveno KJ, Hauth JC, Rouse DJ, Spong CY. Williams Obstetrics. 2010;
  • 5. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998; 280(18): 1569-75[PubMed]
  • 6. Gridelli C, Haiderali AM, Russo MW, Blackburn LM, Lykopoulos K. Casopitant improves the quality of life in patients receiving highly emetogenic chemotherapy. Support Care Cancer. 2010; 18(11): 1437-44[DOI][PubMed]
  • 7. Koren G. Motherisk update. Is ondansetron safe for use during pregnancy? Can Fam Physician. 2012; 58(10): 1092-3[PubMed]
  • 8. Pasternak B, Svanstrom H, Hviid A. Ondansetron in pregnancy and risk of adverse fetal outcomes. N Engl J Med. 2013; 368(9): 814-23[DOI][PubMed]
  • 9. Koren G. Treating morning sickness in the United States--changes in prescribing are needed. Am J Obstet Gynecol. 2014; 211(6): 602-6[DOI][PubMed]
  • 10. King TL, Murphy PA. Evidence-based approaches to managing nausea and vomiting in early pregnancy. J Midwifery Womens Health. 2009; 54(6): 430-44[DOI][PubMed]
  • 11. Sahakian V, Rouse D, Sipes S, Rose N, Niebyl J. Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. Obstet Gynecol. 1991; 78(1): 33-6[PubMed]
  • 12. Ghahiri AA, Abdi F, Mastoo R, Ghasemi M. The Effect of Ondansetron and Metoclopramide in Nausea and Vomiting of Pregnancy. J Isfahan MedSchool. 2011; 29(131)
  • 13. Oliveira LG, Capp SM, You WB, Riffenburgh RH, Carstairs SD. Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. Obstet Gynecol. 2014; 124(4): 735-42[DOI][PubMed]
  • 14. Ondansetron looks safe in pregnancy, so far. BMJ. 2013; 346: 1387[DOI][PubMed]
  • 15. Einarson A, Maltepe C, Navioz Y, Kennedy D, Tan MP, Koren G. The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study. BJOG. 2004; 111(9): 940-3[DOI][PubMed]
  • 16. Anderka M, Mitchell AA, Louik C, Werler MM, Hernandez-Diaz S, Rasmussen SA, et al. Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects. Birth Defects Res A Clin Mol Teratol. 2012; 94(1): 22-30[DOI][PubMed]
  • 17. Shrim A, Boskovic R, Maltepe C, Navios Y, Garcia-Bournissen F, Koren G. Pregnancy outcome following use of large doses of vitamin B6 in the first trimester. J Obstet Gynaecol. 2006; 26(8): 749-51[DOI][PubMed]
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