Journal of Comprehensive Pediatrics

Published by: Kowsar

The Comparison of Oral and IM Dexamethasone Efficacy in Croup Treatment

Gholamreza Soleimani 1 , * , Alireza Daryadel 1 , Alireza Ansari Moghadam 2 and Mohammad Reza Sharif 3
Authors Information
1 Research Center for Children and Adolescents, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
3 Department of Infectious Disease, Kashan University of Medical Sciences, Kashan, IR, Iran
Article information
  • Journal of Comprehensive Pediatrics: November 10, 2013, 4 (4); 175-8
  • Published Online: November 1, 2013
  • Article Type: Research Article
  • Received: February 21, 2012
  • Revised: October 13, 2012
  • Accepted: August 12, 2013
  • DOI: 10.17795/compreped-4528

To Cite: Soleimani G, Daryadel A, Ansari Moghadam A, Sharif M R. The Comparison of Oral and IM Dexamethasone Efficacy in Croup Treatment, J Compr Ped. 2013 ; 4(4):175-8. doi: 10.17795/compreped-4528.

Copyright © 2013, Iranian Society of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Ausejo M, Saenz A, Pham B, Moher D, Chalmers TC, Kellner JD, et al. The effectiveness of glucocorticoids in treating croup: meta-analysis. West J Med. 1999; 171(4): 227-32[PubMed]
  • 2. Rittichier KK, Ledwith CA. Outpatient treatment of moderate croup with dexamethasone: intramuscular versus oral dosing. Pediatrics. 2000; 106(6): 1344-8[PubMed]
  • 3. Cetinkaya F, Tufekci BS, Kutluk G. A comparison of nebulized budesonide, and intramuscular, and oral dexamethasone for treatment of croup. Int J Pediatr Otorhinolaryngol. 2004; 68(4): 453-6[DOI][PubMed]
  • 4. Cherry JD. Clinical practice. Croup. N Engl J Med. 2008; 358(4): 384-91[DOI][PubMed]
  • 5. Westley CR, Cotton EK, Brooks JG. Nebulized racemic epinephrine by IPPB for the treatment of croup: a double-blind study. Am J Dis Child. 1978; 132(5): 484-7[PubMed]
  • 6. Donaldson D, Poleski D, Knipple E, Filips K, Reetz L, Pascual RG, et al. Intramuscular versus oral dexamethasone for the treatment of moderate-to-severe croup: a randomized, double-blind trial. Acad Emerg Med. 2003; 10(1): 16-21[PubMed]
  • 7. Luria JW, Gonzalez-del-Rey JA, DiGiulio GA, McAneney CM, Olson JJ, Ruddy RM. Effectiveness of oral or nebulized dexamethasone for children with mild croup. Arch Pediatr Adolesc Med. 2001; 155(12): 1340-5[PubMed]
  • 8. Amir L, Hubermann H, Halevi A, Mor M, Mimouni M, Waisman Y. Oral betamethasone versus intramuscular dexamethasone for the treatment of mild to moderate viral croup: a prospective, randomized trial. Pediatr Emerg Care. 2006; 22(8): 541-4[DOI][PubMed]
  • 9. Eboriadou M, Chryssanthopoulou D, Stamoulis P, Damianidou L, Haidopoulou K. The effectiveness of local corticosteroids therapy in the management of mild to moderate viral croup. Minerva Pediatr. 2010; 62(1): 23-8[PubMed]
  • 10. Johnson DW, Jacobson S, Edney PC, Hadfield P, Mundy ME, Schuh S. A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup. N Engl J Med. 1998; 339(8): 498-503[DOI][PubMed]
  • 11. Kairys SW, Olmstead EM, O'Connor GT. Steroid treatment of laryngotracheitis: a meta-analysis of the evidence from randomized trials. Pediatrics. 1989; 83(5): 683-93[PubMed]
  • 12. Super DM, Cartelli NA, Brooks LJ, Lembo RM, Kumar ML. A prospective randomized double-blind study to evaluate the effect of dexamethasone in acute laryngotracheitis. J Pediatr. 1989; 115(2): 323-9[PubMed]
  • 13. Kuusela AL, Vesikari T. A randomized double-blind, placebo-controlled trial of dexamethasone and racemic epinephrine in the treatment of croup. Acta Paediatr Scand. 1988; 77(1): 99-104[PubMed]
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