Journal of Comprehensive Pediatrics

Published by: Kowsar

Lifestyle Intervention and Vitamin E Therapy in Obese Children with Nonalcoholic Fatty Liver Disease

Robabeh Ghergherehchi 1 , * , Nazanin Hazhir 1 and Manizheh Mostafa Gharehbaghi 1
Authors Information
1 Pediatric Endocrine Department, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • Journal of Comprehensive Pediatrics: October 25, 2012, 4 (1); 62-5
  • Published Online: October 25, 2012
  • Article Type: Research Article
  • Received: July 5, 2012
  • Revised: September 29, 2012
  • Accepted: October 3, 2012
  • DOI: 10.17795/compreped-6249

To Cite: Ghergherehchi R, Hazhir N, Mostafa Gharehbaghi M. Lifestyle Intervention and Vitamin E Therapy in Obese Children with Nonalcoholic Fatty Liver Disease, J Compr Ped. 2012 ; 4(1):62-5. doi: 10.17795/compreped-6249.

Copyright © 2012, Iranian Society of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Raszeja-Wyszomirska J, Lawniczak M, Marlicz W, Miezynska-Kurtycz J, Milkiewicz P. [Non-alcoholic fatty liver disease--new view]. Pol Merkur Lekarski. 2008; 24(144): 568-71
  • 2. Schwimmer JB, McGreal N, Deutsch R, Finegold MJ, Lavine JE. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics. 2005; 115(5)-5[DOI][PubMed]
  • 3. Yiu D, Leung N. Epidemiological study: nonalcoholic fatty liver disease in Hong Kong Chinese. 2004;
  • 4. Tarantino G, Saldalamacchia G, Conca P, Arena A. Non-alcoholic fatty liver disease: further expression of the metabolic syndrome. J Gastroenterol Hepatol. 2007; 22(3): 293-303[DOI][PubMed]
  • 5. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002; 346(16): 1221-31[DOI][PubMed]
  • 6. Rafeey M, Mortazavi F, Mogaddasi N, Robabeh G, Ghaffari S, Hasani A. Fatty liver in children. Ther Clin Risk Manag. 2009; 5(2): 371-4[DOI][PubMed]
  • 7. Kinugasa A, Tsunamoto K, Furukawa N, Sawada T, Kusunoki T, Shimada N. Fatty liver and its fibrous changes found in simple obesity of children. J Ped Gastroenterol Nutr. 1984; 3(3): 408-14[DOI][PubMed]
  • 8. Reinehr T, Schmidt C, Toschke AM, Andler W. Lifestyle intervention in obese children with non-alcoholic fatty liver disease: 2-year follow-up study. Arch Dis Child. 2009; 94(6): 437-42[DOI][PubMed]
  • 9. Ueno T, Sugawara H, Sujaku K, Hashimoto O, Tsuji R, Tamaki S. Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. J hepat. 1997; 27(1): 103-7[DOI]
  • 10. Uygun A, Kadayifci A, Isik AT, Ozgurtas T, Deveci S, Tuzun A, et al. Metformin in the treatment of patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2004; 19(5): 537-44[DOI][PubMed]
  • 11. Bugianesi E, Gentilcore E, Manini R, Natale S, Vanni E, Villanova N. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol. 2005; 100(5): 1082-90[DOI][PubMed]
  • 12. Lindor KD, Kowdley KV, Heathcote EJ, Harrison ME, Jorgensen R, Angulo P, et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology. 2004; 39(3): 770-8
  • 13. Palmer M, Schaffner F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology. 1990; 99(5): 1408-13
  • 14. Manning PJ, Sutherland WH, Walker RJ, Williams SM, De Jong SA, Ryalls AR. Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects. Diabetes Care. 2004; 27(9): 2166-71
  • 15. Hasegawa T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther. 2001; 15(10): 1667-72
  • 16. Nobili V, Manco M, Devito R, Ciampalini P, Piemonte F, Marcellini M. Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2006; 24(11-12): 1553-61
  • 17. Vajro P, Franzese A, Valerio G, Iannucci MP, Aragione N. Lack of efficacy of ursodeoxycholic acid for the treatment of liver abnormalities in obese children. J Pediatr. 2000; 136(6): 739-43[DOI]
  • 18. Lavine JE. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr. 2000; 136(6): 734-8[DOI][PubMed]
  • 19. Kugelmas M, Hill DB, Vivian B, Marsano L, McClain CJ. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology. 2003; 38(2): 413-9[DOI][PubMed]
  • 20. Wang CL, Liang L, Fu JF, Zou CC, Hong F, Xue JZ, et al. Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children. World J Gastroenterol. 2008; 14(10): 1598-602[DOI][PubMed]
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