Journal of Comprehensive Pediatrics

Published by: Kowsar

The Correlation between Cerebrospinal Fluid and Levels of Serum Zinc and Calcium in Children With Febrile Seizure

Mansour Sadeghzadeh 1 , Samane Nabi 1 , Parisa Khoshnevisasl 1 , * and Nooreddin Mousavinasab 2
Authors Information
1 Department of Pediatrics, Zanjan University of Medical Sciences, Zanjan IR Iran
2 Department of Epidemiology, Zanjan University of Medical Sciences, Zanjan IR Iran
Article information
  • Journal of Comprehensive Pediatrics: November 10, 2013, 4 (4); 179-83
  • Published Online: November 1, 2013
  • Article Type: Research Article
  • Received: May 10, 2013
  • Accepted: June 28, 2013
  • DOI: 10.17795/compreped-12133

To Cite: Sadeghzadeh M, Nabi S, Khoshnevisasl P, Mousavinasab N. The Correlation between Cerebrospinal Fluid and Levels of Serum Zinc and Calcium in Children With Febrile Seizure, J Compr Ped. 2013 ; 4(4):179-83. doi: 10.17795/compreped-12133.

Copyright © 2013, Iranian Society of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Siqueira LF. Febrile seizures: update on diagnosis and management. Rev Assoc Med Bras. 2010; 56(4): 489-92[PubMed]
  • 2. Lin LC, Lee WT, Chen IJ, Yang RC. Lower plasma neuropeptide Y level in patients with atypical febrile convulsions. Kaohsiung J Med Sci. 2010; 26(1): 8-12[DOI][PubMed]
  • 3. Fetveit A. Assessment of febrile seizures in children. Eur J Pediatr. 2008; 167(1): 17-27[DOI][PubMed]
  • 4. Kang JQ, Shen W, Macdonald RL. Why does fever trigger febrile seizures? GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci. 2006; 26(9): 2590-7[DOI][PubMed]
  • 5. Aydin A, Ergor A, Ozkan H. Effects of sociodemographic factors on febrile convulsion prevalence. Pediatr Int. 2008; 50(2): 216-20[DOI][PubMed]
  • 6. Ostergaard JR. Febrile seizures. Acta Paediatr. 2009; 98(5): 771-3[DOI][PubMed]
  • 7. Bacher K, Bogaert E, Lapere R, De Wolf D, Thierens H. Patient-specific dose and radiation risk estimation in pediatric cardiac catheterization. Circulation. 2005; 111(1): 83-9[DOI][PubMed]
  • 8. Srinivasan J, Wallace KA, Scheffer IE. Febrile seizures. Aust Fam Physician. 2005; 34(12): 1021-5[PubMed]
  • 9. Pathirage SP. A study of febrile seizures in children presenting to Teaching Hospital, Kurunegala. Sri Lanka J Child Health. 2010; 39(2)[DOI]
  • 10. Jones T, Jacobsen SJ. Childhood febrile seizures: overview and implications. Int J Med Sci. 2007; 4(2): 110-4[PubMed]
  • 11. Heidarian F, Ashrafzadeh F, Ghasemian A. Serum Zinc level in patients with simple febrile seizure. Iranian J Child Neurol. 2010; 4(2): 41-44
  • 12. Mahyar A, Pahlavan A, Varasteh-Nejad A. Serum zinc level in children with febrile seizure. Acta Medica Iranica. 2008; 46(6): 477-480
  • 13. Ehsanipour F, Talebi-Taher M, Harandi NV, Kani K. Serum zinc level in children with febrile convulsion and its comparison with that of control group. Iran J Pediatr. 2009; 19(1): 65-8
  • 14. Prasad R, Singh A, Das B, Upadhyay R, Singh T, Mishra O. Cerebrospinal fluid and serum zinc, copper, magnesium and calcium levels in children with Idiopathic seizure. J Clin Diagn Res. 2009; 3: 1841-6
  • 15. Sakha K, Barzagar M. Evaluation of Serum Sodium and Ionized Calcium Levels in Febrile Convulsions. Med J Tabriz Med Sci. 2005; 27(1): 43-46
  • 16. Sadeghzadeh M, Khoshnevis Asl P, Mahboubi E. Iron Status and Febrile Seizure-A Case Control Study in Children Less Than 3 Years. Iranian J Child Neurol. 2013; 6(4): 27-31
  • 17. Amiri M, Farzin L, Moassesi ME, Sajadi F. Serum trace element levels in febrile convulsion. Biol Trace Elem Res. 2010; 135(1-3): 38-44[DOI][PubMed]
  • 18. Miyamoto Y, Yamamoto H, Murakami H, Kamiyama N, Fukuda M. Studies on cerebrospinal fluid ionized calcium and magnesium concentrations in convulsive children. Pediatr Int. 2004; 46(4): 394-7[DOI][PubMed]
  • 19. Mollah MA, Rakshit SC, Anwar KS, Arslan MI, Saha N, Ahmed S, et al. Zinc concentration in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: findings from a prospective study in Bangladesh. Acta Paediatr. 2008; 97(12): 1707-11[DOI][PubMed]
  • 20. Mishra A, Mordekar SR, Rennie IG, Baxter PS. False diagnosis of papilloedema and idiopathic intracranial hypertension. Eur J Paediatr Neurol. 2007; 11(1): 39-42[DOI][PubMed]
  • 21. Mollah MA, Dey PR, Tarafdar SA, Akhter S, Ahmed S, Hassan T, et al. Zinc in CSF of patients with febrile convulsion. Indian J Pediatr. 2002; 69(10): 859-61[PubMed]
  • 22. Tutuncuoglu S, Kutukculer N, Kepe L, Coker C, Berdeli A, Tekgul H. Proinflammatory cytokines, prostaglandins and zinc in febrile convulsions. Pediatr Int. 2001; 43(3): 235-9[PubMed]
  • 23. Ganesh R, Janakiraman L. Serum zinc levels in children with simple febrile seizure. Clin Pediatr (Phila). 2008; 47(2): 164-6[DOI][PubMed]
  • 24. Kafadar I, Akinci AB, Pekun F, Adal E. The Role of Serum Zinc Level in Febrile Convulsion Etiology. Çocuk Enfeksiyon Dergisi/J Pediatr Inf. 2012; 6(3): 90-93[DOI]
  • 25. Sayedzadeh SA, Hemati M. Serums Sodium & Calcium Level in Children with Simple and Recurrent Febrile Convulsion. J Kermanshah Univ Med Sci. 2007; 10(4)
  • 26. Nickavar A, Hasanpour H, Sotoudeh K. Validity of Serum Sodium and Calcium Screening in Children with Febrile Convulsion. Acta Medica Iranica. 2009; 47(3): 229-231
  • 27. Papierkowski A, Mroczkowska-Juchkiewicz A, Pawlowska-Kamieniak A, Pasternak K. [Magnesium and zinc levels in blood serum and cerebrospinal fluid in children with febrile convulsions]. Pol Merkur Lekarski. 1999; 6(33): 138-40[PubMed]
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