Journal of Comprehensive Pediatrics

Published by: Kowsar

Use of Recombinant Factor VIIa Utilization Among a Hospitalized Pediatric Population

Nathan E Thompson 1 , * , Melissa Meuler 2 and John P Scott 3
Authors Information
1 Department of Pediatrics Section of Pediatric Critical Care, Medical College of Wisconsin, Milwaukee, USA
2 Pharmacy Practice Resident Children’s Hospital of Wisconsin, Wisconsin, USA
3 Departments of Anesthesiology and Pediatrics, Sections of Pediatric Anesthesiology and Pediatric Critical Care, Wisconsin, USA
Article information
  • Journal of Comprehensive Pediatrics: August 31, 2015, 6 (3); e25505
  • Published Online: August 24, 2015
  • Article Type: Research Article
  • Received: February 20, 2015
  • Revised: May 24, 2015
  • Accepted: June 3, 2015
  • DOI: 10.17795/compreped-25505

To Cite: E Thompson N, Meuler M, P Scott J. Use of Recombinant Factor VIIa Utilization Among a Hospitalized Pediatric Population, J Compr Ped. 2015 ; 6(3):e25505. doi: 10.17795/compreped-25505.

Abstract
Copyright © 2015, Iranian Society of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
References
  • 1. Hedner U. Factor VIIa and its potential therapeutic use in bleeding-associated pathologies. Thromb Haemost. 2008; 100(4): 557-62[PubMed]
  • 2. Logan AC, Goodnough LT. Recombinant factor VIIa: an assessment of evidence regarding its efficacy and safety in the off-label setting. Hematology Am Soc Hematol Educ Program. 2010; 2010: 153-9[DOI][PubMed]
  • 3. [package insert] Coagulation Factor VIIa (Recombinant). 2006;
  • 4. Guzzetta NA, Russell IA, Williams GD. Review of the off-label use of recombinant activated factor VII in pediatric cardiac surgery patients. Anesth Analg. 2012; 115(2): 364-78[DOI][PubMed]
  • 5. Scott JP, Costigan DJ, Hoffman GM, Simpson PM, Dasgupta M, Punzalan R, et al. Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to epsilon-aminocaproic acid in infant cardiac surgery. J Clin Anesth. 2014; 26(3): 204-11[DOI][PubMed]
  • 6. Witmer CM, Huang YS, Lynch K, Raffini LJ, Shah SS. Off-label recombinant factor VIIa use and thrombosis in children: a multi-center cohort study. J Pediatr. 2011; 158(5): 820-825 e1[DOI][PubMed]
  • 7. O'Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006; 295(3): 293-8[DOI][PubMed]
  • 8. Yank V, Tuohy CV, Logan AC, Bravata DM, Staudenmayer K, Eisenhut R, et al. Systematic review: benefits and harms of in-hospital use of recombinant factor VIIa for off-label indications. Ann Intern Med. 2011; 154(8): 529-40[DOI][PubMed]
  • 9. Ponschab M, Landoni G, Biondi-Zoccai G, Bignami E, Frati E, Nicolotti D, et al. Recombinant activated factor VII increases stroke in cardiac surgery: a meta-analysis. J Cardiothorac Vasc Anesth. 2011; 25(5): 804-10[DOI][PubMed]
  • 10. Blatny J, Mathew P, Monagle P, Ovesna P, Fiamoli V. Safety and efficacy of recombinant activated factor VII in nonhemophilia children with severe or life-threatening bleeding: a report from the SeveNBleeP registry. Blood Coagul Fibrinolysis. 2014; 25(4): 326-32[DOI][PubMed]
  • 11. McQuilten ZK, Barnes C, Zatta A, Phillips LE, Haemostasis Registry Steering C. Off-label use of recombinant factor VIIa in pediatric patients. Pediatrics. 2012; 129(6)-40[DOI][PubMed]
  • 12. Pychynska-Pokorska M, Pagowska-Klimek I, Krajewski W, Moll JJ. Use of recombinant activated factor VII for controlling refractory postoperative bleeding in children undergoing cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2011; 25(6): 987-94[DOI][PubMed]
  • 13. Hedner U, Kristensen H, Berntorp E, Ljung R, Petrini P, Tengborn L. Pharmacokinetics of rFVIIa in children. Haemophilia. 1998; 4(3): 355
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments