Journal of Comprehensive Pediatrics

Published by: Kowsar

Response and Recurrence Rate After Treatment With Polyethylene Glycol Versus Polyethylene Glycol Plus Lactulose in Children With Chronic Functional Constipation: A Randomized Controlled Trial

Saleheh Ala 1 , Mahmood Haghighat 2 , Seyed Mohsen Dehghani 3 and Hassan Bazmamoun 4 , *
Authors Information
1 Department of Pediatrics, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of Pediatrics, Nemazee Teaching Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
Article information
  • Journal of Comprehensive Pediatrics: May 01, 2015, 6 (2); e26119
  • Published Online: May 23, 2015
  • Article Type: Research Article
  • Received: December 15, 2014
  • Revised: March 20, 2015
  • Accepted: April 18, 2015
  • DOI: 10.17795/compreped-26119

To Cite: Ala S, Haghighat M, Dehghani S M, Bazmamoun H. Response and Recurrence Rate After Treatment With Polyethylene Glycol Versus Polyethylene Glycol Plus Lactulose in Children With Chronic Functional Constipation: A Randomized Controlled Trial, J Compr Ped. 2015 ; 6(2):e26119. doi: 10.17795/compreped-26119.

Copyright © 2015, Iranian Society of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Sood MR. Rudolph's Pediatrics. 2011; : 1386
  • 2. Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, et al. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology. 2006; 130(5): 1527-37[DOI][PubMed]
  • 3. Rahhal RUA. Pediatric gastrointestinal disease. 2008; : 675-81
  • 4. Uc A, Hyman PE, Walker LS. Functional gastrointestinal disorders in African American children in primary care. J Pediatr Gastroenterol Nutr. 2006; 42(3): 270-4[DOI][PubMed]
  • 5. Baker SS, Liptak GS, Colletti RB, Croffie JM, Di Lorenzo C, Ector W, et al. Constipation in infants and children: evaluation and treatment. A medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1999; 29(5): 612-26[PubMed]
  • 6. Benninga M, Candy DC, Catto-Smith AG, Clayden G, Loening-Baucke V, Di Lorenzo C, et al. The Paris Consensus on Childhood Constipation Terminology (PACCT) Group. J Pediatr Gastroenterol Nutr. 2005; 40(3): 273-5[PubMed]
  • 7. van den Berg MM, van Rossum CH, de Lorijn F, Reitsma JB, Di Lorenzo C, Benninga MA. Functional constipation in infants: a follow-up study. J Pediatr. 2005; 147(5): 700-4[DOI][PubMed]
  • 8. Martinez-Costa C, Palao Ortuno MJ, Alfaro Ponce B, Nunez Gomez F, Martinez-Rodriguez L, Ferre Franch I, et al. [Functional constipation: prospective study and treatment response]. An Pediatr (Barc). 2005; 63(5): 418-25[PubMed]
  • 9. van Ginkel R, Reitsma JB, Buller HA, van Wijk MP, Taminiau JA, Benninga MA. Childhood constipation: longitudinal follow-up beyond puberty. Gastroenterology. 2003; 125(2): 357-63[PubMed]
  • 10. de Lorijn F, van Wijk MP, Reitsma JB, van Ginkel R, Taminiau JA, Benninga MA. Prognosis of constipation: clinical factors and colonic transit time. Arch Dis Child. 2004; 89(8): 723-7[DOI][PubMed]
  • 11. Miele E, Simeone D, Marino A, Greco L, Auricchio R, Novek SJ, et al. Functional gastrointestinal disorders in children: an Italian prospective survey. Pediatrics. 2004; 114(1): 73-8[PubMed]
  • 12. Walia R. M. N. , Khan R, Cuffari C. Chronic Constipation in Children: An Overview Practical gastroenterology. Nutr Issues Gastroenterol . 2013; 119: 19-34
  • 13. Klaschik E, Nauck F, Ostgathe C. Constipation--modern laxative therapy. Support Care Cancer. 2003; 11(11): 679-85[DOI][PubMed]
  • 14. Plunkett A, Phillips CP, Beattie RM. Management of chronic functional constipation in childhood. Paediatr Drugs. 2007; 9(1): 33-46[PubMed]
  • 15. Mason D, Tobias N, Lutkenhoff M, Stoops M, Ferguson D. The APN's guide to pediatric constipation management. Nurse Pract. 2004; 29(7): 13-21[PubMed]
  • 16. van Ginkel R, Buller HA, Boeckxstaens GE, van Der Plas RN, Taminiau JA, Benninga MA. The effect of anorectal manometry on the outcome of treatment in severe childhood constipation: a randomized, controlled trial. Pediatrics. 2001; 108(1)[PubMed]
  • 17. Loening-Baucke V. Constipation and Fecal Incontinence. 2011; [DOI]
  • 18. Whitlock-Morales A, McKeand C, DiFilippo M, Elitsur Y. Diagnosis and treatment of constipation in children: a survey of primary care physicians in West Virginia. W V Med J. 2007; 103(4): 14-6[PubMed]
  • 19. Ip KS, Lee WT, Chan JS, Young BW. A community-based study of the prevalence of constipation in young children and the role of dietary fibre. Hong Kong Med J. 2005; 11(6): 431-6[PubMed]
  • 20. Loening-Baucke V. Constipation and Encopresis. 2001; [DOI]
  • 21. Loening-Baucke V. Prevalence rates for constipation and faecal and urinary incontinence. Arch Dis Child. 2007; 92(6): 486-9[DOI][PubMed]
  • 22. Lee WT, Ip KS, Chan JS, Lui NW, Young BW. Increased prevalence of constipation in pre-school children is attributable to under-consumption of plant foods: A community-based study. J Paediatr Child Health. 2008; 44(4): 170-5[DOI][PubMed]
  • 23. Golder AM, Erhardt JG, Scherbaum V, Saeed M, Biesalski HK, Furst P. Dietary intake and nutritional status of women and pre-school children in the Republic of the Maldives. Public Health Nutr. 2001; 4(3): 773-80[PubMed]
  • 24. Kokke FT, Scholtens PA, Alles MS, Decates TS, Fiselier TJ, Tolboom JJ, et al. A dietary fiber mixture versus lactulose in the treatment of childhood constipation: a double-blind randomized controlled trial. J Pediatr Gastroenterol Nutr. 2008; 47(5): 592-7[PubMed]
  • 25. Loening-Baucke V, Miele E, Staiano A. Fiber (glucomannan) is beneficial in the treatment of childhood constipation. Pediatrics. 2004; 113(3 Pt 1)-64[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments