Journal of Comprehensive Pediatrics

Published by: Kowsar

Prevalence of Metabolic Syndrome in Children With Type 1 Diabetes in South of Iran

Forough Saki 1 , *
Author Information
1 Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Journal of Comprehensive Pediatrics: August 01, 2016, 7 (3); e37703
  • Published Online: August 6, 2016
  • Article Type: Research Article
  • Received: March 9, 2016
  • Revised: June 12, 2016
  • Accepted: July 24, 2016
  • DOI: 10.17795/compreped-37703

To Cite: Saki F. Prevalence of Metabolic Syndrome in Children With Type 1 Diabetes in South of Iran, J Compr Ped. 2016 ; 7(3):e37703. doi: 10.17795/compreped-37703.

Copyright © 2016, Iranian Society of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G. Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. The Lancet. 2009; 373(9680): 2027-33[DOI]
  • 2. van Vliet M, Van der Heyden JC, Diamant M, Von Rosenstiel IA, Schindhelm RK, Aanstoot HJ, et al. Overweight Is Highly Prevalent In Children with Type 1 Diabetes And Associates with Cardiometabolic Risk. J Ped. 2010; 156(6): 923-9[DOI]
  • 3. Soedamah-Muthu SS, Fuller JH, Mulnier HE, Raleigh VS, Lawrenson RA, Colhoun HM. High Risk of Cardiovascular Disease in Patients With Type 1 Diabetes in the U.K.: A cohort study using the General Practice Research Database. Diabetes Care. 2006; 29(4): 798-804[DOI]
  • 4. Łuczyński W, Szypowska A, Głowińska-Olszewska B, Bossowski A. Overweight, obesity and features of metabolic syndrome in children with diabetes treated with insulin pump therapy. Euro J Ped. 2010; 170(7): 891-8[DOI]
  • 5. Krishnan S, Short KR. Prevalence and Significance of Cardiometabolic Risk Factors in Children With Type 1 Diabetes. J CardioMetab Syndr. 2009; 4(1): 50-6[DOI]
  • 6. Ingberg CM, Sarnblad S, Palmer M, Schvarcz E, Berne C, Aman J. Body composition in adolescent girls with Type 1 diabetes. Diabetic Medicine. 2003; 20(12): 1005-11[DOI]
  • 7. Margeirsdottir HD, Larsen JR, Brunborg C, Øverby NC, Dahl-Jørgensen K. High prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes: a population-based study. Diabetologia. 2008; 51(4): 554-61[DOI]
  • 8. Schwab KO, Doerfer J, Hecker W, Grulich-Henn J, Wiemann D, Kordonouri O, et al. Spectrum and Prevalence of Atherogenic Risk Factors in 27,358 Children, Adolescents, and Young Adults With Type 1 Diabetes: Cross-sectional data from the German diabetes documentation and quality management system (DPV). Diabetes Care. 2006; 29(2): 218-25[DOI]
  • 9. Luczyński W, Szypowska A, Bossowski A, Ramotowska A, Rećko P, Rembińska M, et al. Overweight, obesity and metabolic syndrome in children with type 1 diabetes melllitus [in Polish]. Pediatr Endocrinol Diabetes Metab. 2009; 16(2): 83-8
  • 10. Karamizadeh Z, Kamali Sarvestani E, Saki F, Karamifar H, Amirhakimi GH, Namavar Shooshtarian MH, et al. Investigation of osteopontin levels and genomic variation of osteopontin and its receptors in Type 1 diabetes mellitus. J Endocrinol Invest. 2013; 36(11): 1090-3
  • 11. Libman IM, Pietropaolo M, Arslanian SA, LaPorte RE, Becker DJ. Changing Prevalence of Overweight Children and Adolescents at Onset of Insulin-Treated Diabetes. Diabetes Care. 2003; 26(10): 2871-5[DOI]
  • 12. Zimmet P, Alberti KGMM, Kaufman F, Tajima N, Silink M, Arslanian SA, et al. The metabolic syndrome in children and adolescents ? an IDF consensus report. Pediatric Diabetes. 2007; 8(5): 299-306[DOI]
  • 13. Esmaillzadeh A, Mirmiran P, Azadbakht L, Etemadi A, Azizi F. High Prevalence of the Metabolic Syndrome in Iranian Adolescents*. Obesity. 2006; 14(3): 377-82[DOI]
  • 14. Ghassemi H, Harrison G, Mohammad K. An accelerated nutrition transition in Iran. Public Health Nutr. 2006; 5(1a)[DOI]
  • 15. Palomo Atance E, Giralt Muiña P, Ballester Herrera MJ, Ruiz Cano R, León Martín A, Giralt Muiña J. Prevalencia de obesidad y de factores de riesgo cardiovascular en una población de pacientes pediátricos con diabetes tipo 1. Anales de Pediatría. 2013; 78(6): 382-8[DOI]
  • 16. Bonora E, Formentini G, Calcaterra F, Lombardi S, Marini F, Zenari L, et al. HOMA-Estimated Insulin Resistance Is an Independent Predictor of Cardiovascular Disease in Type 2 Diabetic Subjects: Prospective data from the Verona Diabetes Complications Study. Diabetes Care. 2002; 25(7): 1135-41[DOI]
  • 17. Chillarón JJ, Goday JA, Flores L. Estimated glucose disposal rate in assessment of the metabolic syndrome and microvascular complications in patients with type 1 diabetes. J Clin Endocrinol Metab. 2009; 94: 3530-4[DOI]
  • 18. Petitti DB. Serum Lipids and Glucose Control. Am J Dis Child. 2007; 161(2): 159[DOI]
  • 19. van Vliet M, von Rosenstiel IA, Schindhelm RK, Brandjes DPM, Beijnen JH, Diamant M. Ethnic differences in cardiometabolic risk profile in an overweight/obese paediatric cohort in the Netherlands: a cross-sectional study. Cardiovasc Diabetol. 2009; 8(1): 2[DOI]
  • 20. Basiratnia M, Derakhshan D, Ajdari S, Saki F. Prevalence of childhood obesity and hypertension in south of Iran. .Iran J Kidney Dis. 7(4): 282-9
  • 21. Harrison DG, Guzik TJ, Lob HE, Madhur MS, Marvar PJ. Inflammation, immunity, and hypertension. Hypertension. 2011; 57: 132-40
  • 22. Verlohren S, Muller DN, Luft FC, Dechend R. Immunology in Hypertension, Preeclampsia, and Target-Organ Damage. Hypertension. 2009; 54(3): 439-43[DOI]
  • 23. Schiffrin EL. T lymphocytes: a role in hypertension? Curr Opin Nephrol Hypertens. 2010; 19(2): 181-6[DOI]
  • 24. De Ciuceis C, Amiri F, Brassard P, Endemann DH, Touyz RM. Reduced Vascular Remodeling, Endothelial Dysfunction, and Oxidative Stress in Resistance Arteries of Angiotensin II-Infused Macrophage Colony-Stimulating Factor-Deficient Mice: Evidence for a Role in Inflammation in Angiotensin-Induced Vascular Injury. Arterioscler, Thromb, Vasc Biol. 2005; 25(10): 2106-13[DOI]
  • 25. Ko EA, Amiri F, Pandey NR, Javeshghani D, Leibovitz E, Touyz RM, et al. Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. AJP: Heart Circ Physiol. 2006; 292(4)-95[DOI]
  • 26. Kumar P, Krishna P, Reddy SC, Gurappa M, Aravind SR, Munichoodappa C. Incidence of type 1 diabetes mellitus and associated complications among children and young adults: results from Karnataka Diabetes Registry 1995-2008. J Indian Med Assoc. 2008; 106(11): 708-11
  • 27. Ferreira-Hermosillo A, Vargas-Ortega G, González-Virla B. Prevalence of metabolic syndrome (MS) in patients with type 1 diabetes (DM1). Gac Med Mex. 2012; 148: 137-43
  • 28. Mooradian AD, Haas MJ, Wong NCW. Transcriptional Control of Apolipoprotein A-I Gene Expression in Diabetes. Diabetes. 2004; 53(3): 513-20[DOI]
  • 29. Hassan K, Loar R, Anderson BJ, Heptulla RA. The role of socioeconomic status, depression, quality of life, and glycemic control in type 1 diabetes mellitus. J Ped. 2006; 149(4): 526-31[DOI]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments