Journal of Comprehensive Pediatrics

Published by: Kowsar

Complications of Bacillus Calmette-Guérin Vaccination at a University Hospital in Iranian Neonates

Soheila Siroosbakht 1 and Bijan Rezakhaniha 2 , *
Authors Information
1 Department of Pediatrics, Military University of Medical Sciences, Tehran, Iran
2 Faculty of Medicine, Military University of Medical Sciences, Tehran, Iran
Article information
  • Journal of Comprehensive Pediatrics: February 28, 2019, 10 (1); e67098
  • Published Online: November 27, 2018
  • Article Type: Research Article
  • Received: February 4, 2018
  • Revised: June 13, 2018
  • Accepted: August 2, 2018
  • DOI: 10.5812/compreped.67098

To Cite: Siroosbakht S, Rezakhaniha B. Complications of Bacillus Calmette-Guérin Vaccination at a University Hospital in Iranian Neonates, J Compr Ped. 2019 ; 10(1):e67098. doi: 10.5812/compreped.67098.

Copyright © 2018, Journal of Comprehensive Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Chacon-Cruz E, Arellano-Estrada JL, Lopatynsky-Reyes E, Alvelais-Palacios J, Becka C. Children with lymphadenitis associated with Bacillus Calmette-Guerin (BCG) vaccination do not experience more infections when compared with BCG-vaccinated children without lymphadenitis: A three years paired-cohort in Mexico. Ther Adv Vaccines. 2017;5(4-5):103-7. doi: 10.1177/2051013617741585. [PubMed: 29201375]. [PubMed Central: PMC5697593].
  • 2. Teo SS, Smeulders N, Shingadia DV. BCG vaccine-associated suppurative lymphadenitis. Vaccine. 2005;23(20):2676-9. doi: 10.1016/j.vaccine.2004.07.052. [PubMed: 15780451].
  • 3. Hawkridge A, Hatherill M, Little F, Goetz MA, Barker L, Mahomed H, et al. Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: Randomised trial. BMJ. 2008;337. a2052. doi: 10.1136/bmj.a2052. [PubMed: 19008268]. [PubMed Central: PMC2583390].
  • 4. Hatipoglu N, Guvenc BH, Deswarte C, Koksalan K, Boisson-Dupuis S, Casanova JL, et al. Inherited IL-12Rbeta1 deficiency in a child with BCG adenitis and oral candidiasis: A case report. Pediatrics. 2017;140(5). doi: 10.1542/peds.2016-1668. [PubMed: 29025965]. [PubMed Central: PMC5654388 conflicts of interest to disclose].
  • 5. Baek SO, Ko HS, Han HH. BCG vaccination-induced suppurative lymphadenitis: Four signs to pay attention to. Int Wound J. 2017;14(6):1385-7. doi: 10.1111/iwj.12755. [PubMed: 28425207].
  • 6. Bolursaz MR, Lotfian F, Velayati AA. Bacillus Calmette-Guerin vaccine complications in Iranian children at a university hospital. Allergol Immunopathol (Madr). 2017;45(4):356-61. doi: 10.1016/j.aller.2016.10.006. [PubMed: 28161281].
  • 7. Lotte A, Wasz-Hockert O, Poisson N, Dumitrescu N, Verron M, Couvet E. BCG complications. Estimates of the risks among vaccinated subjects and statistical analysis of their main characteristics. Adv Tuberc Res. 1984;21:107-93. [PubMed: 6475644].
  • 8. Behjati M, Ayatollahi J. Post BCG lymphadenitis in vaccinated infants in Yazd, Iran. Iran J Pediatr. 2008;18(4):351-6.
  • 9. Seyfhashemi M, Hamedi A, Mazaheri M, Azarbarin A, Hamedi P. Complication of BCG vaccination in children. Iran J Pediatr. 2005;15(3):209-14.
  • 10. Tidajani O, Amedome A. The protective effect of BCG vaccination of the newborn against childhood tuberculosis in Chile. Tubercle J. 1985;67:269-81.
  • 11. Ray CS, Pringle D, Legg W, Mbengeranwa OL. Lymphadenitis associated with BCG vaccination: A report of an outbreak in Harare, Zimbabwe. Cent Afr J Med. 1988;34(12):281-6. [PubMed: 3252979].
  • 12. Sirinavin S, Chotpitayasunondh T, Suwanjutha S, Sunakorn P, Chantarojanasiri T. Protective efficacy of neonatal Bacillus Calmette-Guerin vaccination against tuberculosis. Pediatr Infect Dis J. 1991;10(5):359-65. [PubMed: 2067885].
  • 13. Milstien JB, Gibson JJ. Quality control of BCG vaccine by WHO: A review of factors that may influence vaccine effectiveness and safety. Bull World Health Organ. 1990;68(1):93-108. [PubMed: 2189588]. [PubMed Central: PMC2393003].
  • 14. Praveen KN, Smikle MF, Prabhakar P, Pande D, Johnson B, Ashley D. Outbreak of Bacillus Calmette-Guerin-associated lymphadenitis and abscesses in Jamaican children. Pediatr Infect Dis J. 1990;9(12):890-3. [PubMed: 2277745].
  • 15. Jeena PM, Chhagan MK, Topley J, Coovadia HM. Safety of the intradermal Copenhagen 1331 BCG vaccine in neonates in Durban, South Africa. Bull World Health Organ. 2001;79(4):337-43. [PubMed: 11357213]. [PubMed Central: PMC2566397].
  • 16. de Souza GRM, Sant'Anna CC, e Silva JRL, Mano DB, Bethlem NM. Intradermal BCG vaccination complications—analysis of 51 cases. Tuberculosis. 1983;64(1):23-7.
  • 17. Jou R, Huang WL, Su WJ. Tokyo-172 BCG vaccination complications, Taiwan. Emerg Infect Dis. 2009;15(9):1525-6. doi: 10.3201/eid1509.081336. [PubMed: 19788832]. [PubMed Central: PMC2819856].
  • 18. Casanova JL, Blanche S, Emile JF, Jouanguy E, Lamhamedi S, Altare F, et al. Idiopathic disseminated bacillus Calmette-Guerin infection: A French national retrospective study. Pediatrics. 1996;98(4 Pt 1):774-8. [PubMed: 8885960].
  • 19. Fretzayas A, Moustaki M, Stefos E, Nicolaidou P. Splitting the dose of neonatal BCG vaccination: A naive practice. Ann Trop Paediatr. 2009;29(3):243-5. doi: 10.1179/027249309X12467994694210. [PubMed: 19689870].
  • 20. Alrabiaah AA, Alsubaie SS, Bukhari EI, Gad A, Alzamel FA. Outbreak of Bacille Calmette-Guerin-related lymphadenitis in Saudi children at a university hospital after a change in the strain of vaccine. Ann Saudi Med. 2012;32(1):4-8. [PubMed: 22156633]. [PubMed Central: PMC6087637].
  • 21. Middelburg TA, Snels DG, van Praag MC, Rudolphus A, Arend SM, Verhard EM, et al. A rare complication of BCG vaccination. Int J Dermatol. 2009;48(5):546-8. doi: 10.1111/j.1365-4632.2009.03644.x. [PubMed: 19416395].
  • 22. Brantsaeter AB, Romanus V, Andersen PH, Heldal E. Evidence of protective effect of BCG vaccination in persons at low risk of tuberculosis in Nordic countries. Int J Tuberc Lung Dis. 2009;13(4):440-5. [PubMed: 19335948].

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