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Upper Limits of Normal Aminotransferases in Children of Southern Iran

AUTHORS

Seyed Mohsen Dehghani 2 , * , Asma Erjaee 1 , Mahmood Haghighat 1 , Mohammad Hadi Imanieh 2 , Razieh Ahmadi 1

AUTHORS INFORMATION

2 Shiraz Transplant Research Center, School of Medicine, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran

1 Gastroenterohepatology Research Center, School of Medicine, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran

ARTICLE INFORMATION

Journal of Comprehensive Pediatrics: 5 (1); 15274
Published Online: February 1, 2014
Article Type: Research Article
Received: October 5, 2013
Accepted: December 7, 2013
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Abstract

Background: Alanine aminotransferase (ALT) level is the most common diagnostic test used for detection of liver damage; however in the past few years some studies have questioned the normal aminotransferase range in adults and have suggested its revision.

Objectives: In this study, we assessed the upper limit of ALT and aspartate transaminase (AST) in a healthy population of Iranian children.

Patients and Methods: A total of 500 apparently healthy children, aged 1 - 15 years, were enrolled in the study. Each patient's serum AST, ALT, triglyceride, cholesterol, and fasting blood sugar were checked. Participants with low or high body mass indexes as well as abnormal lipid profiles and fasting blood sugars were excluded from the study.

Results: A total of 340 subjects with a mean age of 9.2 3.5 years were included in the study. According to our study we reported the 95th percentile of ALT values, corresponding to the upper limit of normal in healthy individuals, as 21 U/L for children. Furthermore, the 95th percentile of AST values, corresponding to the upper limit of normal range in healthy children, was 29 U/L.

Conclusions: A clearly lower cutoff of normality for liver enzyme values in children of our population was demonstrated in this study. However, age and gender were not found to be determining factors for upper limit of normal range for ALT in children.

Keywords

Aminotransferases Normal Children

© 2014, Journal of Comprehensive Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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