Paraclinical Evolutions Regarding Liver and Renal Abnormalities of Kawasaki Disease in the Southeast of Iran

AUTHORS

Gholamreza Soleimani 1 , * , Simin Sadeghi Bojd 1 , Mahsa Tajik 1 , Elham Shafighi Shahri 1 , Somayeh Rashidi 1

1 Children and Adolescents Health Research Center, Ali-Ebne-Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, IR Iran

How to Cite: Soleimani G, Sadeghi Bojd S, Tajik M, Shafighi Shahri E, Rashidi S. Paraclinical Evolutions Regarding Liver and Renal Abnormalities of Kawasaki Disease in the Southeast of Iran, J Compr Ped. 2014 ; 5(1):15777. doi: 10.17795/compreped-15777.

ARTICLE INFORMATION

Journal of Comprehensive Pediatrics: 5 (1); 15777
Published Online: February 9, 2014
Article Type: Research Article
Received: October 27, 2013
Accepted: January 7, 2014
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Abstract

Background: Kawasaki disease (KD) is a vasculitis affecting multi-organ systems including liver and kidneys. KD is diagnosed by some clinical criteria including sterile pyuria, microscopic hematuria, proteinuria due to renal involvement, liver abnormalities manifesting as abnormal liver function tests, gallbladder hydrops, and hypoalbuminemia.

Objectives: The aim of the study was to determine the frequency of liver and renal abnormalities in patients with KD, hospitalized in Ali-Ebne-Abitaleb Hospital of Zahedan during 2006 - 2013.

Materials and Methods: Paraclinical findings including serum and urine tests as well as gallbladder ultrasonography of 47 patients with KD hospitalized in Ali-Ebne-Abitaleb Hospital of Zahedan during 2006 - 2013 were reviewed retrospectively.

Results: Liver abnormalities were found in 22 (46.8%) cases and impaired liver function tests were more common than other liver abnormalities in this cross-sectional study. The incidence of abnormal liver function tests in this study was about 42%. Gallbladder hydrops were found in 6 (12.7%) patients and 18 (38.3%) had renal involvement. Sterile pyuria was the most common urine abnormality with incidence of 36.2%. Microscopic hematuria and proteinuria were rarely found; in addition, serum urea nitrogen and creatinine had normal levels in all patients.

Conclusions: The possibility of KD should be considered in any infants or children with abnormal results in liver or renal function tests. Paraclinical findings of liver and renal involvements of all patients were partly similar to the previous studies.

Keywords

Kawasaki Disease Hydrops Renal Failure

© 2014, Journal of Comprehensive Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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