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Type of Immunodeficiency, Treatment and Outcomes of Serious BCG Vaccine Complications: A 15 Year Survey

AUTHORS

Samileh Noorbakhsh 1 , Ahmad Siadati 2 , Setareh Mamishi 2 , Lida Fereidoni 2 , Jalil Kooh Paiezadeh 2

1 Assistant Professor of Pediatric Infectious Disease, Research center of pediatric infectious diseases, Iran University of Medical Sciences, 9121823797

2 Professor of Pediatric Infectious Disease, Research center of pediatric infectious diseases, Central Children Hospital. Tehran University of Medical Sciences

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How to Cite: Noorbakhsh S, Siadati A, Mamishi S, Fereidoni L, Kooh Paiezadeh J. Type of Immunodeficiency, Treatment and Outcomes of Serious BCG Vaccine Complications: A 15 Year Survey, J Compr Ped. Online ahead of Print ; 1(2):43-47.

ARTICLE INFORMATION

Journal of Comprehensive Pediatrics: 1 (2); 43-47
Article Type: Research Article
Received: January 1, 2007
Accepted: January 1, 2007

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Abstract

Background:To describe the immunologic characteristics and outcomes of the patients with serious BCG complication in a 15- year survey.
Materials and Methods: A descriptive and retrospective study was performed in 2 referral pediatric infectious wards of central Children Hospital, and Rasool Akram Hospital Tehran, Iran between 1989 and 2004.
Results: We studied 76 patients (72% male and 28% female) with serious BCG complications. mean age of 14.41± 1.43 months the results were follows:severe combined immunodeficiency 15.7 % of cases Leukopenia 1.4%; lymphopenia in 2.8%; cell mediated immunodeficiency in 26.3 %, chronic granulomatous disease in 11.2%, common variable immunodeficiency 6.5 %; NK cell deficiency in 5.2%; isolated CD4 deficiency in 5.1 %; hyper IgM syndrome in 1.4 %, mild abnormality in nitroblue tetrazolium (NBT) test 4.2 %;mild hypogammaglobulinemia in 4.2 % and idiopathic disseminated BCG infection in 15.7% of patients.Nineteen patients died due to progressive disseminated mycobacterial infections.
Conclusion: N.k cell deficiency has yet reported as a risk factor for progression and complication of BCG infection. we suggest combination therapy with IFN-? and chemotherapy in all cases of" idiopathic disseminated BCG infections.

Keywords

BCG compliacation Gamma Interferon BCG vaccine Immunodeficiency

© 0, Journal of Comprehensive Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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