Journal of Comprehensive Pediatrics

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Nutritional Status in Iranian Non-Syndromic Patients with Acyanotic Congenital Heart Disease Undergoing Surgical Repair

Ehsan Aghaei-Moghadam 1 , Mohammad Reza Mirzaaghayan 1 , Ali-Akbar Zeinaloo 1 , Elaheh Malakan Rad 1 , Keyhan Sayadpour Zanjani 1 , Amir Hossein Alavi 1 , Hassan Radmehr 1 , Ali Mohebbi 2 , Azadeh Sayarifard 2 , Marjan Kouhnavard 3 , Zeinab Gholibeigian 1 , Sima Amini 1 and Azin Ghamari 1 , *
Authors Information
1 Tehran University of Medical Sciences, Tehran, Iran
2 Growth and Development Research Center, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3 Children’s Medical Center, Pediatric Center of Excellence, Tehran, Iran
Article information
  • Journal of Comprehensive Pediatrics: In Press (In Press); e86639
  • Published Online: May 12, 2019
  • Article Type: Research Article
  • Received: November 21, 2018
  • Accepted: January 7, 2019
  • DOI: 10.5812/compreped.86639

To Cite: Aghaei-Moghadam E, Mirzaaghayan M R, Zeinaloo A, Malakan Rad E, Sayadpour Zanjani K, et al. Nutritional Status in Iranian Non-Syndromic Patients with Acyanotic Congenital Heart Disease Undergoing Surgical Repair, J Compr Ped. Online ahead of Print ; In Press(In Press):e86639. doi: 10.5812/compreped.86639.

Copyright © 2019, Journal of Comprehensive Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Menon G, Poskitt EM. Why does congenital heart disease cause failure to thrive? Arch Dis Child. 1985;60(12):1134-9. doi: 10.1136/adc.60.12.1134. [PubMed: 4091578]. [PubMed Central: PMC1777687].
  • 2. Gilger MJC, Kessler B, Nanjundiah P, Klish WJ. Nutrition, growth, and the gastrointestinal system: Basic, knowledge for the pediatric cardiologist. In: Garson A, Bricker JT, McNamara DG, editors. The science and practice of, pediatric cardiology. Philadelphia: Lea and Febiger; 1990. p. 2354-70.
  • 3. Medoff-Cooper B, Naim M, Torowicz D, Mott A. Feeding, growth, and nutrition in children with congenitally malformed hearts. Cardiol Young. 2010;20 Suppl 3:149-53. doi: 10.1017/S1047951110001228. [PubMed: 21087573].
  • 4. Varan B, Tokel K, Yilmaz G. Malnutrition and growth failure in cyanotic and acyanotic congenital heart disease with and without pulmonary hypertension. Arch Dis Child. 1999;81(1):49-52. doi: 10.1136/adc.81.1.49. [PubMed: 10373135]. [PubMed Central: PMC1717989].
  • 5. Thommessen M, Heiberg A, Kase BF. Feeding problems in children with congenital heart disease: The impact on energy intake and growth outcome. Eur J Clin Nutr. 1992;46(7):457-64. [PubMed: 1623850].
  • 6. Naeye RL. Anatomic features of growth failure in congenital heart disease. Pediatrics. 1967;39(3):433-40. [PubMed: 6018974].
  • 7. Man WD, Weber M, Palmer A, Schneider G, Wadda R, Jaffar S, et al. Nutritional status of children admitted to hospital with different diseases and its relationship to outcome in The Gambia, West Africa. Trop Med Int Health. 1998;3(8):678-86. doi: 10.1046/j.1365-3156.1998.00283.x. [PubMed: 9735938].
  • 8. Pelletier DL, Frongillo EA Jr, Habicht JP. Epidemiologic evidence for a potentiating effect of malnutrition on child mortality. Am J Public Health. 1993;83(8):1130-3. doi: 10.2105/AJPH.83.8.1130. [PubMed: 8342721]. [PubMed Central: PMC1695164].
  • 9. Salzer HR, Haschke F, Wimmer M, Heil M, Schilling R. Growth and nutritional intake of infants with congenital heart disease. Pediatr Cardiol. 1989;10(1):17-23. doi: 10.1007/BF02328630. [PubMed: 2495525].
  • 10. Roman B. Nourishing little hearts: Nutritional implications for congenital heart defects. Pract Gastroenterol. 2011;35(8):11-34.
  • 11. Kliegman RM, Stanton BMD, Geme JS, Schor NF. Nelson textbook of pediatrics. Elsevier; 2015.
  • 12. Schroeder DG, Brown KH. Nutritional status as a predictor of child survival: Summarizing the association and quantifying its global impact. Bull World Health Organ. 1994;72(4):569-79. [PubMed: 7923536]. [PubMed Central: PMC2486600].
  • 13. Campbell M, Reynolds G. The physical and mental development of children with congenital heart disease. Arch Dis Child. 1949;24(120):294-302. doi: 10.1136/adc.24.120.294. [PubMed: 15401798]. [PubMed Central: PMC1988282].
  • 14. Bayer LM, Robinson SJ. Growth history of children with congenital heart defects. Size according to sex, age decade, surgical status, and diagnostic category. Am J Dis Child. 1969;117(5):564-72. doi: 10.1001/archpedi.1969.02100030566011. [PubMed: 5781709].
  • 15. Vaidyanathan B, Roth SJ, Rao SG, Gauvreau K, Shivaprakasha K, Kumar RK. Outcome of ventricular septal defect repair in a developing country. J Pediatr. 2002;140(6):736-41. doi: 10.1067/mpd.2002.124304. [PubMed: 12072879].
  • 16. Mirzaaghayan MR, Aghaei Moghadam E, Dehestani A, Ghamari A. Early surgical closure of the ventricular septal defects; to be done or not to be done? A question to be answered. Iran J Pediatr. 2018;In Press(In Press). doi: 10.5812/ijp.58876.
  • 17. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39(12):1890-900. doi: 10.1016/S0735-1097(02)01886-7. [PubMed: 12084585].
  • 18. Blasquez A, Clouzeau H, Fayon M, Mouton JB, Thambo JB, Enaud R, et al. Evaluation of nutritional status and support in children with congenital heart disease. Eur J Clin Nutr. 2016;70(4):528-31. doi: 10.1038/ejcn.2015.209. [PubMed: 26695725].
  • 19. Ackerman IL, Karn CA, Denne SC, Ensing GJ, Leitch CA. Total but not resting energy expenditure is increased in infants with ventricular septal defects. Pediatrics. 1998;102(5):1172-7. doi: 10.1542/peds.102.5.1172. [PubMed: 9794950].
  • 20. Farrell AG, Schamberger MS, Olson IL, Leitch CA. Large left-to-right shunts and congestive heart failure increase total energy expenditure in infants with ventricular septal defect. Am J Cardiol. 2001;87(9):1128-31. A10. doi: 10.1016/S0002-9149(01)01479-5. [PubMed: 11348620].
  • 21. van der Kuip M, Hoos MB, Forget PP, Westerterp KR, Gemke RJ, de Meer K. Energy expenditure in infants with congenital heart disease, including a meta-analysis. Acta Paediatr. 2003;92(8):921-7. doi: 10.1111/j.1651-2227.2003.tb00625.x. [PubMed: 12948067].
  • 22. Trabulsi JC, Irving SY, Papas MA, Hollowell C, Ravishankar C, Marino BS, et al. Total energy expenditure of infants with congenital heart disease who have undergone surgical intervention. Pediatr Cardiol. 2015;36(8):1670-9. doi: 10.1007/s00246-015-1216-3. [PubMed: 26092599].
  • 23. Hong BJ, Moffett B, Payne W, Rich S, Ocampo EC, Petit CJ. Impact of postoperative nutrition on weight gain in infants with hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2014;147(4):1319-25. doi: 10.1016/j.jtcvs.2013.06.044. [PubMed: 23998784].
  • 24. Schwalbe-Terilli CR, Hartman DH, Nagle ML, Gallagher PR, Ittenbach RF, Burnham NB, et al. Enteral feeding and caloric intake in neonates after cardiac surgery. Am J Crit Care. 2009;18(1):52-7. doi: 10.4037/ajcc2009405. [PubMed: 19116405].
  • 25. Malagon I, Onkenhout W, Klok M, van der Poel PF, Bovill JG, Hazekamp MG. Gut permeability in neonates after a stage 1 Norwood procedure. Pediatr Crit Care Med. 2005;6(5):547-9. doi: 10.1097/01.PCC.0000175990.72753.97. [PubMed: 16148815].
  • 26. Harrison AM, Davis S, Reid JR, Morrison SC, Arrigain S, Connor JT, et al. Neonates with hypoplastic left heart syndrome have ultrasound evidence of abnormal superior mesenteric artery perfusion before and after modified Norwood procedure. Pediatr Crit Care Med. 2005;6(4):445-7. doi: 10.1097/01.PCC.0000163674.53466.CA. [PubMed: 15982432].
  • 27. Nicholson GT, Clabby ML, Kanter KR, Mahle WT. Caloric intake during the perioperative period and growth failure in infants with congenital heart disease. Pediatr Cardiol. 2013;34(2):316-21. doi: 10.1007/s00246-012-0448-8. [PubMed: 22890625].
  • 28. Norris MK, Hill CS. Nutritional issues in infants and children with congenital heart disease. Crit Care Nurs Clin North Am. 1994;6(1):153-63. doi: 10.1016/S0899-5885(18)30516-1. [PubMed: 8192875].
  • 29. Leitch CA. Growth, nutrition and energy expenditure in pediatric heart failure. Prog Pediatr Cardiol. 2000;11(3):195-202. doi: 10.1016/S1058-9813(00)00050-3. [PubMed: 10978712].
  • 30. Okoromah CA, Ekure EN, Lesi FE, Okunowo WO, Tijani BO, Okeiyi JC. Prevalence, profile and predictors of malnutrition in children with congenital heart defects: A case-control observational study. Arch Dis Child. 2011;96(4):354-60. doi: 10.1136/adc.2009.176644. [PubMed: 21266339]. [PubMed Central: PMC3056291].
  • 31. Cameron JW, Rosenthal A, Olson AD. Malnutrition in hospitalized children with congenital heart disease. Arch Pediatr Adolesc Med. 1995;149(10):1098-102. doi: 10.1001/archpedi.1995.02170230052007. [PubMed: 7550812].
  • 32. Leite HP, de Camargo Carvalho AC, Fisberg M. [Nutritional status of children with congenital heart disease and left-to-right shunt. The importance of the presence of pulmonary hypertension]. Arq Bras Cardiol. 1995;65(5):403-7. Portuguese. [PubMed: 8729856].
  • 33. Vaidyanathan B, Nair SB, Sundaram KR, Babu UK, Shivaprakasha K, Rao SG, et al. Malnutrition in children with congenital heart disease (CHD) determinants and short term impact of corrective intervention. Indian Pediatr. 2008;45(7):541-6. [PubMed: 18695271].
  • 34. Sempé M, Pédron G, Roy-Pernot MA. [Auxology, method and sequences]. Bulletin Memoir Anthropol Soc Paris. 1979:77. French.
  • 35. Unger R, DeKleermaeker M, Gidding SS, Christoffel KK. Calories count. Improved weight gain with dietary intervention in congenital heart disease. Am J Dis Child. 1992;146(9):1078-84. doi: 10.1001/archpedi.1992.02160210080026. [PubMed: 1514555].
  • 36. de Onis M, Blössner M. World Health Organization global database on child growth and malnutrition. Program of nutrition. Geneva: WHO; 1997.
  • 37. WHO Multicentre Growth Reference Study Group. WHO child growth standards based on length/height, weight and age. Acta Paediatr Suppl. 2006;450:76-85. doi: 10.1111/j.1651-2227.2006.tb02378.x. [PubMed: 16817681].
  • 38. Forchielli ML, McColl R, Walker WA, Lo C. Children with congenital heart disease: A nutrition challenge. Nutr Rev. 1994;52(10):348-53. doi: 10.1111/j.1753-4887.1994.tb01359.x. [PubMed: 7816352].
  • 39. Freeman LM, Roubenoff R. The nutrition implications of cardiac cachexia. Nutr Rev. 1994;52(10):340-7. doi: 10.1111/j.1753-4887.1994.tb01358.x. [PubMed: 7816351].
  • 40. Ross RD, Bollinger RO, Pinsky WW. Grading the severity of congestive heart failure in infants. Pediatr Cardiol. 1992;13(2):72-5. doi: 10.1007/BF00798207. [PubMed: 1614922].

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