Comparison of Intramuscular Injection of Single-Dose Ceftriaxone and Oral Amoxicillin in Acute Otitis Media in Children

AUTHORS

Ali Akbar Rahbarimanesh 1 , Houshang Akhtarharari 1 , Peiman Salamati 1 , Afshin shirkani 1 , *

1 Pediatric Department of Tehran University of Medical Sciences, 2 Social Medicine Department of Tehran University of Medical Sciences

How to Cite: Rahbarimanesh A A, Akhtarharari H, Salamati P, shirkani A. Comparison of Intramuscular Injection of Single-Dose Ceftriaxone and Oral Amoxicillin in Acute Otitis Media in Children, J Compr Ped. 2007 ; 1(2):e93742.

ARTICLE INFORMATION

Journal of Comprehensive Pediatrics: 1 (2); e93742
Published Online: December 30, 2007
Article Type: Research Article
Received: May 15, 2019
Accepted: December 30, 2007

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Abstract

Background: The present study evaluated efficacy of a single injection of ceftriaxone 50mg/kg IM in comparison with a 10- day treatment course with oral amoxicillin 50mg/kg/d in 3 divided doses for acute otitis media in children. Materials and Methods: A randomized clinical trial was performed on 110 children between 5 months to 12yr who randomly were divided in to ceftriaxone group (n=54) and amoxicillin group (n=56) as case and control groups, respectively. Results: Demographic data and clinical manifestations of patients were similar in both groups. Forty-eight (88.9%) and 51 (91%) patients were cured in case and control groups, respectively. There was no significant different in response to therapy between the two group (p<0.05). Conclusion: This study showed that the efficacy of single injection of ceftriaxone 50mg/kg IM was equal to a 10-day treatment course with oral amoxicillin 50mg/kg/d divided in 3 doses in non-complicated acute otitis media in children.

Keywords

ceftriaxone Amoxicillin Acute otitis media

© 2007, Journal of Comprehensive Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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